Studies on Acetylenic Compounds. XXXVII. The Cyclization Reaction of Some Propargylammonium Halide Derivatives. (2)
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The cyclization reaction of ortho-ethynylbenzaldehyde derivatives into isoquinoline derivatives.
In order to elucidate the reaction mechanism of the cyclization between an ethynyl group and an imino group at the ortho-position on an aromatic ring to afford isoquinolines, reaction of 2-ethynylbenzaldehydes under various conditions was examined. It is concluded that reaction proceeds via an ionic process and the isoquinoline 4-hydrogen atom derives from the solvent. In addition, it was found...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1964
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.12.813